In line with these findings, FBXL6 promoted HCC cell migration and upregulation of metastasis markers (Icam1, Vcam1, Upa, Ccl2, and Mmp9) (Supplementary Fig. 3c, d), while silencing FBXL6 blocked these effects (Supplementary Fig. 3e–g). Here, ICAM1 is linked to hepatocellular carcinoma.