The promotive effects on metastasis in these mice were much stronger than those in mice with Kras mutation (KrasLSL-G12D/+;Alb-Cre), p53 haploinsufficiency (p53+/–) or Tsc1 insufficiency (Tsc1fl/fl;Alb-Cre), as indicated by the tumor number, largest tumor size, liver/body weight ratio, and rate of lung metastasis (Fig. 1d–h). This evidence concerns the gene TP53 and neoplasm.