FBXL6 and hepatocellular carcinoma: IHC staining of 108 paired HCC samples (tumor tissues and adjacent normal tissues from the same patients) revealed that FBXL6 was overexpressed in 60.2% (65/108) of the HCC tissues compared to the paired adjacent tissues and was positively associated with advanced TNM stage, vascular thrombosis, and metastasis (Fig. 1b, Supplementary Table 1).