To test the interaction between FBXL6 and TKT, we performed a co-IP experiment and found that FBXL6 was able to interact with TKT, whereas the previously reported potential substrates of FBXL6 (HSP90, CCNA2, and VDAC2) had low or no binding affinity compared with that of TKT in HCC cells (Fig. 2b, Supplementary Fig. 6a, b). This evidence concerns the gene CCNA2 and hepatocellular carcinoma.