In addition, previously reported potential substrates of FBXL6, including CCNA2 and VDAC2, were not involved in the oncogenic role of FBXL6 in HCC, as indicated by the low binding affinity of these proteins for FBXL6 compared with that of TKT, suggesting that TKT is the predominant substrate of FBXL6. Here, VDAC2 is linked to hepatocellular carcinoma.