Previous literature indicated that AKT-mediated TKT phosphorylation at Thr382 is associated with its activation in mice fed a lysine-deficient diet35, whereas we found that only Thr287 in TKT was phosphorylated in HCC tumors with high FBXL6 expression, indicating that TKT phosphorylation at Thr287 may play a critical role in FBXL6-mediated TKT ubiquitination. Here, AKT1 is linked to hepatocellular carcinoma.