Therefore, both REDD1 and TXNIP may be involved in the pathogenesis of neurological disorders and neurodegenerative diseases by inhibiting protein synthesis and ROS-mediated oxidative stress2; however, the REDD1−NF-κB pathway may also play a role, as inflammation is a contributing factor to neurodegenerative diseases148. This evidence concerns the gene DDIT4 and neurodegenerative disease.