DDIT4 and systemic lupus erythematosus: DEX activates autophagy in mouse thymocytes and murine lymphoma cells through REDD1 induction3, and autophagy is frequently activated in T cells and B cells from a lupus mouse model and in blood mononuclear cells from patients with systemic lupus erythematosus (SLE)161, indicating that REDD1-mediated autophagy is associated with SLE.