Dual-color IF staining showed that blocking eIF5Ahpu by GC-7 treatment reduced tumor infiltration of total F4/80+ macrophages and the proportion of F4/80+/CD206+ macrophages (Fig. 7E, F) as well as CD206+/ARG1+ and CD206+/HO-1+ M2-like macrophages (Supplementary Fig. 8) in tumor microenvironment. The gene discussed is ARG1; the disease is neoplasm.