SRM and head and neck squamous cell carcinoma: Herein, TCGA dataset analysis revealed that the mRNA expression levels of ODC1, SRM, SMOX, and EIF5A2 genes are significantly higher in HPV- HNSCC tissues than that in HPV+ HNSCC tissues (Fig. 1), suggesting that polyamine-eIF5A2 axis may play an important role in the aggressiveness and progression of HPV- HNSCC.