PTPRD and multiple sclerosis: Previous studies of cross-sectional BV and Multiple Sclerosis Severity Score (MSSS) have also reported sub-significant associations with variants in the PTPRD region independent from our BV change peak (cross sectional BV top SNP: top SNP: rs1953594, adjusted trend − logP = 4.3; MSSS top SNP: rs10977017, p = 1.02 × 10–5)5,6.