VWF and hypertensive disorder: There is endothelial dysfunction in hypertensive patients, which is manifested by increased levels of vascular cell adhesion molecule-1 (sVCAM-1), soluble intercellular adhesion molecule-1 (sICAM-1), and von Willebrand Factor (vWF) in mediating vessel injury in hypertension, which leads to high levels of circulating pro-inflammatory cytokines7–9.