After entering the systemic circulation, tropomyosin receptor kinase B (TrkB) is overexpressed on the tumor cell membrane, which activates phosphatidylinositol 3-kinase (PI3K)-protein kinase B (Akt) signal pathway5, and up-regulates some cell surface proteins (CD47, etc.)to inhibit macrophage phagocytosis6. Here, AKT1 is linked to neoplasm.