The main findings of this study are: (1) Increased expression of p-PI3K/p-Akt/p-WNK1 signal pathway in spinal dorsal root ganglion of bone cancer mice; (2) Up-regulated expression of IL-17, TNF-α and WNK1 in mice with bone cancer pain; (3) Inhibition of Akt protein, decreased expression of WNK1 in blood and WNK1 in spinal dorsal root ganglion of mice with bone cancer pain. This evidence concerns the gene AKT1 and bone cancer.