The main findings of this study are: (1) Increased expression of p-PI3K/p-Akt/p-WNK1 signal pathway in spinal dorsal root ganglion of bone cancer mice; (2) Up-regulated expression of IL-17, TNF-α and WNK1 in mice with bone cancer pain; (3) Inhibition of Akt protein, decreased expression of WNK1 in blood and WNK1 in spinal dorsal root ganglion of mice with bone cancer pain. Here, AKT1 is linked to bone neoplasm.