LRP8 and Parkinson disease: In addition, using western blot analysis based LRP8 knockout mice models, have shown that LRP8 knockout increases the phosphorylation level of the microtubule-stabilising protein tau (MAPT)29.A previous retrospective study including 855 caucasian PD patients found a suggestive association between the H1b MAPT haplotype and a higher likelihood of dyskinesia at an initial visit30.