The gray density WB results showed that the ratio of Bax/Bcl‐2 in the neuronal cells of the mice in the KO group was significantly higher than that in the WT group (Figure 8c,d); this was consistent with previous TUNEL staining results, indicating that MEX3C gene deletion enhanced neuronal apoptosis through autophagy inhibition, which, in turn, led to the formation of cognitive impairment in mice. Here, BCL2 is linked to Cognitive impairment.