CD4 and juvenile idiopathic arthritis: Although no significant differences were observed regarding the frequency of Tfh (CD4+CD25-FoxP3-CD45RO+CXCR5+) and Tfr (CD4+CD25+FoxP3+CXCR5+) cells, we found that Th1-like Tfh (CXCR3+CCR6−) cells were significantly decreased in extended oligo JIA and poly JIA patients, contrarily to Th17-like (CXCR3-CCR6+) Tfh cells that were significantly increased when compared with controls.