Nevertheless, regarding Tfh cell subpopulations, when using CXCR3/CCR6 expression classification system, we found that children with extended oligo+poly JIA, but not persistent oligo JIA patients, had significantly lower frequencies of Th1-like Tfh (Tfh1, CXCR3+CCR6−) cells and higher frequencies of Th17-like Tfh (Tfh17, CXCR3-CCR6+) cells when compared with controls (figure 4A). The gene discussed is CXCR3; the disease is juvenile idiopathic arthritis.