ICOS and juvenile idiopathic arthritis: Moreover, we have also observed that the frequencies of PD1+ICOS+Tfh cells and Th1-like Tfh cells were significantly correlated with JADAS-27 in persistent oligo JIA and extended oligo+poly JIA patients, respectively (figure 4E) No major significant differences were found in the frequencies and absolute numbers of total CD3+T cells and their subpopulations in adult JIA patients when compared with healthy controls (online supplemental figure 1B).