Nonetheless, only Th2-like and Th17-like Tfh cells are able to activate B cells and promote production of immunoglobulins.56 In this study, we found an imbalance in circulating Tfh cell subsets, but not in Tfr cells, in children with extended oligo JIA and poly JIA in comparison to healthy controls. Here, TFRC is linked to juvenile idiopathic arthritis.