To determine whether astrocytes ingest synapses in human brain, we examined colocalization between GFAP and Syn1 (Figure 1A) and observe a 2.1-fold increase in AD compared with age-matched control brain (Figure 1B), indicating astrocytes ingest more synapses in AD than control (p < 0.0001). This evidence concerns the gene SYN1 and Alzheimer disease.