OspC type A strains, which have the highest rates of dissemination in this study (S4 Fig) and previous reports in mice and humans [6,7], and have been linked to more severe symptoms of Lyme disease [6] (S4C Fig), are strongly associated with a set of approximately 75 loci (OR > 50) including a DbpA homology group (OR 4964, p = 2.1 x 10−49, likelihood ratio test), an OspC homology group (OR 2951, p = 2.9 x 10−49, likelihood ratio test), and BB_H26 (OR 2186, p = 6.3 x 10−40, likelihood ratio test) (S9 Table). Here, YBX3 is linked to Lyme disease.