PDCD1 and neoplasm: Interestingly, in scRNA-Seq analysis, one of the T cell markers, Pdcd1 (29, 30), was elevated during TREM1 silencing, and our flow cytometry data further confirmed this observation, wherein TREM1 deficiency or VJDT treatment induced significant increases in tumor-infiltrating CD8+PD-1+ T cells within the TME (Figure 2, C and D and Supplemental Figure 1, K and L).