CCR2 and neoplasm: scRNA-Seq analysis revealed that TREM1 inhibition led to decreased frequency of CCR2-expressing tumor-infiltrating myeloid cells as well as downregulation of the CCR2/CCL2 axis and CX3CR1 and CXCL2 chemokines, which are key players in the tumor-homing pathways responsible for MDSC accumulation in the TME (76, 77).