In addition, among the tumor-infiltrating lymphocytes (TILs), TREM1 deficiency led to significant attenuation in exhausted CD8+ T (T Exh) cells (CD8+Tim-3+CTLA-4+) (26) (Figure 1, G and H, Supplemental Figure 1, G and H, and Supplemental Figure 3C) while increasing the proportion of cytotoxic CD8+ T (T Cyt) cells (CD8+GzmB+CD25+) (27) (Figure 1, I and J, Supplemental Figure 1, I and J, and Supplemental Figure 3D). The gene discussed is CTLA4; the disease is neoplasm.