Interestingly, VJDT monotherapy induced expansion of an iNKT cluster classified by the expression of Cxcl10, Icos, Traj18, and Klra5, while combinational treatment, which yielded the lowest tumor volumes, showed an increased presence of both MAIT cells and Rorc-expressing DNTαβ cells (Supplemental Figure 4B). Here, ICOS is linked to neoplasm.