Lead DEGs in the immunity and inflammatory GOBPs enriched in the PLCG1-low subgroup were largely overlapping and included genes such as TNFSF13 (APRIL), implicated in B cell survival and differentiation in RCC (18), as well as ASAH1 (19) and XRCC6 (20), implicated in T cell function (Figure 1F). The gene discussed is XRCC6; the disease is renal cell carcinoma.