The change in immunosuppressive cytokine expression in the Vegfr2Y1173F/+ tumor microenvironment, which exhibits reduced production of Tgfb1, Tgfb2, Il10, Il12a, and Ebi3, supports the notion that suppressed PLCγ signaling in the endothelium stabilizes the vascular barrier, boosting antitumor immunity. The gene discussed is IL12A; the disease is neoplasm.