Furthermore, activation of eNOS was suppressed in VEGFA-stimulated iECs from Vegfr2Y1173F/+ mice, relative to iECs from WT mice (Figure 5, D and E), as well as in tumor vessels in B16F10 melanoma growing in Vegfr2 Y1173F/+ mice (Figure 5, F and G). Here, NOS3 is linked to neoplasm.