VHL and nonpapillary renal cell carcinoma: In contrast, GOBPs enriched in the PLCG1-high subgroup related to proliferative and morphogenic processes, including lymph vessel morphogenesis, in agreement with the loss of the hypoxia-regulated von Hippel Lindau (vHL) tumor suppressor and hypoxia-induced expression of VEGFA in ccRCC (21) (Figure 1, G and H).