EBI3 and neoplasm: The change in immunosuppressive cytokine expression in the Vegfr2Y1173F/+ tumor microenvironment, which exhibits reduced production of Tgfb1, Tgfb2, Il10, Il12a, and Ebi3, supports the notion that suppressed PLCγ signaling in the endothelium stabilizes the vascular barrier, boosting antitumor immunity.