As expected, global LR analysis revealed increased metabolic activation (Lrp1, Lpl, App, Apoe), regulation of cellular migration (Adipoq, Igf1, Thbs1, Apoe), regulation of tissue remodeling (Cola1, Cola2), and regulation of immune response (Cd36, Cd81, C3) (Figure 7, A–D, and Supplemental Figure 19) as predominant biological processes associated with obesity-induced eWAT remodeling. The gene discussed is IGF1; the disease is obesity due to melanocortin 4 receptor deficiency.