APOE and obesity due to melanocortin 4 receptor deficiency: As expected, global LR analysis revealed increased metabolic activation (Lrp1, Lpl, App, Apoe), regulation of cellular migration (Adipoq, Igf1, Thbs1, Apoe), regulation of tissue remodeling (Cola1, Cola2), and regulation of immune response (Cd36, Cd81, C3) (Figure 7, A–D, and Supplemental Figure 19) as predominant biological processes associated with obesity-induced eWAT remodeling.