To verify the role of UPR receptors in the generation of procoagulant EVs from pancreatic adenocarcinoma cells, we evaluated the effect of X-box binding protein 1 (XBP1) and PERK depletion on EV-mediated thrombin generation using a plasma-based thrombin generation assay. Here, XBP1 is linked to pancreatic adenocarcinoma.