In PWH, a number of studies have found associations between depression and biomarkers of immune activation and inflammation such as CRP, IL-6, and soluble cluster of differentiation-14 (sCD14; Lu et al. 2019; Norcini Pala et al. 2016; Rivera-Rivera et al. 2016; Stewart et al. 2020), even in PWH who are virally suppressed (Ellis et al. 2020). Here, CRP is linked to major depressive disorder.