The role of p73 in cancer is complicated due to the presence of multiple p73 isoforms that coordinate in a complex way to exert both oncogenic and non-oncogenic activities (Dulloo et al., 2015b; Nemajerova et al., 2018; Rufini et al., 2011; Stiewe and Pützer, 2002; Amelio et al., 2015). This evidence concerns the gene TP73 and cancer.