Male and female mice treated with multiple low-dose STZ developed comparable hyperglycaemia (P < 0.001, Fig. 1A and B), in conjunction with reduced plasma and pancreatic insulin concentrations (P < 0.01, Fig. 1C and D) and impaired glucose tolerance (P < 0.001, Fig. 1E and F) when compared to control mice. Here, INS is linked to Hyperglycemia.