Overall, seven downstream genes (TRPM6, ABR, MME, MMP8, MT-ND4L, LTF, and KCNJ15) corresponded to hsa_circ_0067209/hsa-miR-8082, and eight genes (ADAMTS1, NEFL, RGS16, MYOM2, EFNB2, MDGA1, RORC, and CD248) were the downstream targets of hsa_circ_0000673/hsa-miR-1248 as interaction networks in the COPD process (Figure 9A,B). Here, MMP8 is linked to chronic obstructive pulmonary disease.