ROS may also be correlated to the silencing of the immuneresponseto cancer: the myeloid-derived suppressor cells (MDSC), responsiblefor ROS-dependent immune suppression in tumors, showed high ROS levelsin different kind of tumors.164,165 Notably, the lackof NOX2 activity has been related to the MDSC loss of the abilityto suppress the response of T cells, thus suggesting that NOX2 isstrictly associated with ROS-induced immune suppression by MDSC. This evidence concerns the gene CYBB and cancer.