REN and type 2 diabetes mellitus: For example, compound 9 showed renoprotective effects in a mouse model of type 2diabetes, while compound 10 proved to be helpful in preventinghypertensive cardiac remodeling in hypertensive rats induced by abdominalartery coarctation.215,216 In October 2013, compound 10 entered a clinical trial to evaluate its efficacy in oraladministration in type 2 diabetes patients with maximal inhibitionof the renin-angiotensin-aldosterone system and residual albuminuria.217 The study concluded in March 2015, but theresults are still not available.