Korkina and co-workers suggested that one of thehallmarks of the drug resistance was the alteration of the redox homeostasis.160 The high expression of NOX1 promotes intracellularROS generation, thus activating the HIF-1α/MDR1 pathway to speedup the chemoresistance in gallbladder cancer cells.161 Moreover, HIF-1α prompts the expression of P-glycoprotein,which incites chemoresistance in prostate cancer cells.162 Therefore, all of these findings confirm thatNOX1 is closely related to the development of drug resistance in cancer. This evidence concerns the gene ABCB1 and Familial prostate cancer.