CYBB and COVID-19: Specifically,compared to controls, SARS-CoV-2 infected patients displayed overactivationof NOX2, which was more marked in subjects with thrombotic complications,indicating a role in thrombotic-related ischemic events.103 More recently, the induction of NOX2 and NOX5in the cardiac microvascular endothelium was also reported, even ifthe exact roles of NOXs in the pathogenesis of COVID-19 remain tobe elucidated.104