In addition, 19 reduced hypertension andaortic wall inflammation in a mouse model of AngII-induced vascularoxidative stress.84 However, a followingstudy by Bach and co-workers raised concerns about this compound asa NOX2 inhibitor.230 Indeed, 19 was shown to be hydrolyzed in standard aqueous buffer and was notable to inhibit the p47phox/p22phox interaction.Moreover, cellular studies for 19 demonstrated a weakNOX2 inhibitory activity (IC50 of 54 μM), comparableto that of the catechol hydrolysis product. This evidence concerns the gene CYBB and hypertensive disorder.