An interesting study demonstrated thecorrelation between expressionsof the NOX regulatory subunits and BRCA1 gene in ovarian cystadenocarcinoma,lung adenocarcinoma, and breast invasive carcinoma, suggesting thatthe high expression of regulatory subunits of NOX1 and NOX4 are relatedto the downregulation of BRCA1 gene expression, and these events maybe associated with the progression of malignancy.158. This evidence concerns the gene BRCA1 and ovarian cystadenocarcinoma.