CYBB and amyotrophic lateral sclerosis: The IGF1 signaling pathway canbe disrupted as a result of a NOX-dependent mechanism that causesoxidative changes in receptors.131 Transgenicmice for superoxide dismutase-1 (SOD1), a well-known hallmark of ALS,showed NOX1/NOX2-dependent oxidative stress that has been linked tothe progression of motor neuron disease.