AGT and hypertensive disorder: Under pathological conditions (i.e., hypertension,diabetes, andatherosclerosis), Ang II stimulates NOX hyperactivation, which inturn promotes numerous processes, including the synthesis of proinflammatorymediators, expression of adhesion cells, increased vascular permeability,and calcification.76−79 Several studies in animal models have confirmed the role of NOXactivation in the development of Ang II-induced hypertension.