HIF1A and gallbladder cancer: Korkina and co-workers suggested that one of thehallmarks of the drug resistance was the alteration of the redox homeostasis.160 The high expression of NOX1 promotes intracellularROS generation, thus activating the HIF-1α/MDR1 pathway to speedup the chemoresistance in gallbladder cancer cells.161 Moreover, HIF-1α prompts the expression of P-glycoprotein,which incites chemoresistance in prostate cancer cells.162 Therefore, all of these findings confirm thatNOX1 is closely related to the development of drug resistance in cancer.