NOX5 and melanoma: Despite the field of NOX5 biology still beingin its infancy, ithas been proven that NOX5 expression and activity are increased ingastric cancer, malignant melanoma, and breast, prostate, and esophagealcancers.173−175 Different pathways are implicated in theseNOX5-ROS-dependent processes, showing an increased expression of NOX5connected to signaling molecules like MAP kinases and transcriptionfactors (i.e., p53 and β-catenin).173,176 NOX5 has also been shown to be related to the sensitivity of cancercells to chemotherapeutic drugs such as cisplatin.