Moreover,a reduced neurotoxicity and cognitive decline have been observed inneuronal-targeted NOX4 knockdown, supporting the direct involvementof NOX4 in accumulation of tau proteins.129 Higher NOX4 levels have also been found in astrocytes of the cerebralcortex from AD patients, leading to disruption of mitochondrial metabolismand oxidative stress. This evidence concerns the gene NOX4 and Alzheimer disease.