NOX4 and hypertensive disorder: Forexample, global knockout of NOX1 or NOX2 has been shown to protectagainst Ang II-induced hypertension, and higher mRNA levels of NOX1,NOX2, and NOX4 were found in the aortas of Ang II-infused animals.80−84 In addition, it has been reported that NOX5 is upregulated in culturedhuman endothelial cells.85