IFNG and neoplasm: In B16OVA, substantial concentrations of IL-12 could be measured in the interstitial fluid of tumors injected with the mRNA encoding IL-12 and IL-12-taFv1 (Figure S4A, left panel), and as a result, increased concentrations of IFNγ were also measurable in such recovered tumor interstitial fluid (Figure S4A, right panel).