MAPT and Alzheimer disease: By contrast, the APPSwDI/Nos2−/− (CVN-AD) mice develop amyloid plaques and tau pathology, including hyperphosphorylated tau and the accumulation of neurofibrillary tangles, and exhibit neuron loss and learning and memory deficits reminiscent of human AD (Wilcock et al., 2008; Colton C. et al., 2014).