RGS4 and schizophrenia: Additionally, in organotypic brain slice cultures, genetic or pharmacological inhibition of RGS4 (Regulator of G-protein Signaling 4), a putative susceptibility gene for schizophrenia, resulted in a decrease in xCT expression and Sxc– activity, which was accompanied by reduced glutamate levels, the latter of which was ameliorated by NAC (Huang et al., 2018).