Cancer cells reprogram mature adipocytes into CAAs through delipidation and acquiring a fibroblast-like phenotype, which is accompanied by the loss of expression of adipocyte terminal differentiation markers, such as adiponectin, leptin, and fatty acid binding protein (FABP2) and an increase in the secretion of pro-inflammatory cytokines, such as Interleukin 6 (IL-6) and plasminogen activator inhibitor-1 (PAI-1), as well as proteases, such as matrix metalloproteinase 9 (MMP9) and MMP11 (Andarawewa et al., 2005; Dirat et al., 2011). Here, SERPINE1 is linked to cancer.