AKT1 and neoplasm: GL could inhibit TF-1 cells proliferation in vitro and reduce the volume of TF-1 tumor via inhibiting the activation of AKT/mTOR/signal transducer and activator of transcription 3 (STAT3) signaling pathway, attenuating the expression of cyclin D1 and survivin and increasing the cleavage of caspase-3 and PARP (He et al., 2015).