Meanwhile, GL incubation effectively reduced the expression of Treg specific markers (Forkhead Box P3, glucocorticoid-induced TNFR-related protein and cytotoxic T lymphocyte antigen 4), phospho-STAT3, COX-2 and prostaglandin E2 in melanoma cells, finally limiting the progression of melanoma (Juin et al., 2020). Here, FOXP3 is linked to melanoma.