MAPK8 and hepatocellular carcinoma: A recent study has shown that GL administration led to a decrease in stem cell pluripotency and induced the differentiation in HCC in vitro and in vivo by targeting c-Jun N-terminal kinase 1 (JNK1) (Cai et al., 2019); Importantly, blockage of JNK1 mitigate the degree of malignancy of HCC (Cai et al., 2019).