In the PD-1/PD-L1 immunosuppression axis panel, PD-L1 was highly expressed on tumor cells and macrophages, while PD-1 was more co-expressed with ICs, PD-1+CD3+CD8+, and PD-L1+CD3+CD8+ ICs were less abundant in TILs (Figure 1E, Figure S2C). This evidence concerns the gene CD274 and neoplasm.