Similar to what we observed in KPC; cKO mice, nude mice injected with Kindlin-2 knockdown MIA PaCa-2 cells showed less tumor burden compared to mice injected with control cells (Figure 2L-N), further confirming the pro-tumorigenic effects of Kindlin-2 on pancreatic cancer. This evidence concerns the gene FERMT2 and familial pancreatic carcinoma.