Recently, a high-throughput aorta smooth muscle OoC device replicated the abnormal activation of HIF-1α observed in aortas from thoracic aortic aneurysm patients, and finally identified the two most effective drugs (2-methoxyestradiol and digoxin) from the seven specific HIF-1α inhibitors 49. Here, HIF1A is linked to thoracic aortic aneurysm.