In EndoTrackEGFP mice that were subjected to partial carotid ligation and 5-Aza of control injection, a pronounced endothelial expression (indicated by Tek-Cre-EGFP) of pSmad2/3 (indicated by white signals) was observed in control mice in LCA where disturbed flow was experimentally generated; the pSmad2/3 level was markedly reduced in LCA upon administration with 5-Aza (Figure 5F). The gene discussed is TEK; the disease is Leber congenital amaurosis.