Most importantly, compared with the Glu-containing [68Ga]Ga-HTK03041, the Aad-derived [68Ga]Ga-HTK03149 (Figure 2A, X = CH2) showed not only comparable uptake in PSMA-expressing LNCaP tumor xenografts (23.1 ± 6.11 vs 19.1 ± 6.37 %ID/g, 1 h post-injection), but also > 95% reduction in kidney (170±26.4 vs 4.15±1.46 %ID/g, 1 h post-injection) and salivary gland (4.99±0.88 vs 0.22 ± 0.06 %ID/g, 1 h post-injection) uptake 11-12. Here, FOLH1 is linked to neoplasm.