Consistent with the MesoMT and fibrosis, which are critical processes for cancer peritoneal metastasis 16, the expressions of MesoMT-related and fibrosis-related gene sets, including mesenchymal factors (CDH2, VIM, ACTA2), MesoMT-related factors (SERPINE1, VEGFA, VEGFB) and extracellular matrix (ECM) remodeling factors (TNC, FN1, MMP2, ICAM1, ECM1) were increased in the PMCs of the LCP group (Figure 2C). This evidence concerns the gene ECM1 and cancer.