CLDN1 and lung cancer: Co-culture of PMC (MeT-5A) with human lung cancer cells (EGFR wild type cancer cell lines: A549 and CL1-5; EGFR mutation cancer cell lines: H1975 and HCC827) also showed that lung cancer cells induced the MesoMT in MeT-5A cells, as supported by the upregulation of mesenchymal factors, Vimentin, and downregulation of the epithelial marker, Claudin-1 (Figure 2F).