Moreover, inhibition of GPX4 impaired the cell viability of GPX4 high-expressing A549 and H1975 cells cultured in the fluid of MPE, whereas overexpression of GPX4 rescued cell death from MPE in GPX4 low-expressing HCC827 cells, supporting the theory that ferroptosis resistance may be an essential factor related to pleural metastasis in lung cancer. Here, GPX4 is linked to lung cancer.