Treatment with 2-APB Figure S4A-C) and CLT (Figure S4D-F) markedly attenuated cisplatin-induced cytotoxicity in these tumor cell lines, examined by the CCK-8 assays, Conversely, incubation with ADPR, a TRPM2 activator, dramatically increased tumor cell death following treatment with cisplatin (Figure S4G-I). The gene discussed is TRPM2; the disease is neoplasm.