It was found that neutrophil ROS and NET formation are regulated by the NCF1-339 genotype and that the NCF1-339 SNP-mediated decrease in NADPH oxidase function is associated with high interferon activity and impaired formation of NETs in SLE, permitting a dependence on mitochondrial ROS (Linge et al., 2020). Here, NCF1 is linked to systemic lupus erythematosus.