Interestingly, GHRH agonist JI-34 also attenuated LPS- and pneumolysin (LPY)-induced endothelial dysfunction in human lung microvascular endothelial cells (HL-MVEC), while having no effect on inflammation (59), suggesting that GHRH agonists and antagonists may elicit similar protective effects in specific settings. This evidence concerns the gene GHRH and endothelial dysfunction.