With concurrent ARDS (0=no, 1=yes) as the dependent variable, age, gender, lung infection, mechanical ventilation, septic shock, APACHE II score, SOFA score, diabetes mellitus, hypertension, hyperlipidemia, coronary heart disease, smoking history, and serum NLRP3 concentration were independent variables, and irrelevant items were gradually excluded (p>0.05). This evidence concerns the gene NLRP3 and acute respiratory distress syndrome.