NLRP3 and acute respiratory distress syndrome: It was found that patients with sepsis and ARDS had higher serum NLRP3 concentrations at baseline in patients who died at 28-day follow-up (Figure 3A, p<0.001), and the baseline serum NLRP3 levels had a significant predictive value for 28-day death (Figure 3B, p<0.001).