The heatmap showed that the 15 CpG sites (located on B3GALNT1, C6orf97, FAM72A, FAM72B, LIFR, OSMR, ZNF264, and ZNF543) well‐distinguished CRC from adjacent normal tissues (Figure 2A), WBCs (Figure 2B), and 28 other types of cancer (Figure 2C) in TCGA, as well as 23 other types of cancer in GEO (Supporting information). Here, ZNF543 is linked to colorectal carcinoma.