APOE and metabolic syndrome: In the logistic multivariate analyses, considering the variables age, sex, APOE E4 allele, hypertension, diabetes, and dyslipidemia, pathological amyR was significantly associated with a higher likelihood of having pathological p-tau/Aβ42 [cut-off ≥ 0.086: OR 23.3 with a 95% CI of 4.0980–28.4627, p < 0.001; cut-off ≥ 0.122: OR 8.8 with a 95% CI of 3.28–23.68, p < 0.001] (Table 3).