IGHE and asthma: Sex-stratified EWAS analyses detected four male-specific dmCpGs that mapped to genes associated with vital capacity (KCNJ1, MYADML2), IgE levels (relevant to asthma pathogenesis) [46], as well as to genes linked with low-density lipoprotein measurement/ total cholesterol (TRIM2) and BMI-related phenotypes (GRAMD4, MYADML2, KCNJ1).