TIMP1 and amyloidosis: These findings are supported by the results of our study, in which we confirm the upregulation of MMP9 and Timp1 in perivascular macrophages associated with vascular amyloid deposits, strongly suggesting engagement of perivascular macrophages with vascular amyloid and anti-Aβ antibodies are associated with preponderant extracellular matrix remodeling and leakage of blood plasma proteins.