The APOE-\documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$\epsilon 4$$\end{document}ε4 allele was not associated with MCI in SOL-INCA, but APOE region SNPs substantially contributed to the association of AD PRS with MCI. The gene discussed is APOE; the disease is Alzheimer disease.