IL36A and congenital rubella syndrome: It has been shown that [15] IL-36α, IL-36β and IL-36γ stimulate nasal mucosal vascular endothelial cells to cause increased permeability in patients with CRS, while in AR, an inflammatory disease of the nasal mucosa with a similar inflammatory pattern, IL-36α may also cause nasal congestion by acting on nasal mucosal vascular endothelial cells to increase vascular permeability, exudate plasma and inflammatory substances, and form local mucosal edema.