Interestingly, in our recent work examining the interactions between cancer-associated fibroblasts and MDA+ and MDA− phenotypically sorted subpopulations, we found that MDA+ microvesicles were enriched for matrix metalloproteinase-14 (MMP-14) [10], a multi-functional proteinase that degrades ECM proteins such as collagen I and activates ERK signaling, both of which facilitate cancer cell invasion [25–28]. The gene discussed is MMP14; the disease is cancer.