ACSL4 and colitis: Herein, we found that GQD administration obviously improved the levels of ferroptosis markers (iron load, MDA, GSH, and mitochondrial morphology) and the expression of ferroptosis-associated proteins (GPX4, SLC7A11 and ACSL4) in the colon after DSS challenge, which illustrated that GQD protects against DSS-induced colitis by inhibiting ferroptotic cell death in IECs.