Moreover, overexpression of RGS2 significantly reduces thrombin-induced intracellular Ca2+ transportation [110], whereas the up-regulated intracellular Ca2+ promotes the proliferation and differentiation of fibroblasts, induces fibroblast-to-myofibroblasts conversion [111], leads to apoptosis of type II lung cells [112], and ultimately gives rise to the formation of pulmonary fibrosis. The gene discussed is RGS2; the disease is pulmonary fibrosis.