Researchers found that hypertension in selected human populations, a single nucleotide polymorphism (SNP, rs4606) located in the 3’-untranslated region (UTR) of RGS2 gene is correlated with PE [77] and the same SNP (rs4606) is closely associated with an increased risk in PE development, particularly in a population of overweight females [82–84]. Here, RGS2 is linked to hypertensive disorder.