The half year after delivery is considered as a high-risk period for depression, with the prevalence rate from 13 to 19% [95]. Current research on antidepressant therapy and pathogenesis of depression is focused on the depression-like behavior phenotype [96], and some researchers have discovered that the mice with depression-like behavior have a high level of Rgs2 expression [97]. The gene discussed is RGS2; the disease is major depressive disorder.