Phenotypic enrichment analysis found that 9 PSGs (AKAP11, ARHGAP35, BMP7, GPC3, NEK1, PMEPA1, ROBO1, RSPO2, and SLC26A7) were closely associated with increased urine osmolality, hydroureter, polycystic kidney, and kidney development. Here, PMEPA1 is linked to medical procedure.