Phenotypic enrichment analysis found that 9 PSGs (AKAP11, ARHGAP35, BMP7, GPC3, NEK1, PMEPA1, ROBO1, RSPO2, and SLC26A7) were closely associated with increased urine osmolality, hydroureter, polycystic kidney, and kidney development. This evidence concerns the gene NEK1 and urogenital neoplasm.