Nevertheless, little is known about its potential role in tumour diagnosis and targeted therapy.<h4>Findings</h4>The results of the study demonstrated that the interaction of BNIP3 with HDAC1 may affect the progression of breast invasive cancer (BRCA), sarcoma (SARC), kidney renal clear cell carcinoma (KIRC), and low-grade glioma (LGG). The gene discussed is BNIP3; the disease is low grade glioma.