In addition, we also investigated the relationship between TCIRG1 expression and the clinicopathological characteristics in KIRC patients, and found that the expression level of TCIRG1 was higher in KIRC patients with poorer tumor differentiation, lymph node metastasis, and high clinical stage (Fig. 3D-F). This evidence concerns the gene TCIRG1 and metastatic malignant neoplasm in the lymph nodes.