CD8A and neoplasm: Scatter plots showed that TCIRG1 expression was significantly positively correlated with the infiltration of CD4+T cell Th1 (Rho = 0.277, P < 0.001), CD8+T cell (Rho = 0.341, P < 0.001), NK cell (Rho = 0.418, P < 0.001), and M1 macrophage (r = 0.261, P < 0.001) (Fig. 4C), suggesting that TCIRG1 may promote the tumor immune response in ccRCC by positively regulating CD4+T cell Th1, CD8+T cell, NK cell, and M1 macrophage.