The data showed that co-incubation with target-positive NKTCL cells could significantly increase the expression of CD25 and HLA-DR in both the CD4 + and CD8 + subgroups of CAR-T cells (Fig. 3a, b, Additional file 1: Figs. S3-S4). This evidence concerns the gene CD4 and extranodal nasal NK/T cell lymphoma.