In addition, it has been reported that in the bcl-7 mutant of Caenorhabditis elegans, the nuclei in stem cells, which are called seam cells in this organism, and the nuclei in the human stomach cancer cell line (the Kato III cell line) are enlarged when BCL7B expression is downregulated by siRNA [9]. The gene discussed is BCL7B; the disease is gastric cancer.