TSC1 and tuberous sclerosis: Tuberous sclerosis complex (TSC) is a rare autosomal dominant genetic syndrome with an approximate incidence of 1 in 5000–10,000 live births.1,2 TSC patients have a mutation in the TSC1 or TSC2 genes, which encode for hamartin and tuberin, respectively.1,3 These inactivating mutations result in the deregulation of the mammalian target to rapamycin (mTOR) pathway.